NeuroTechnology Studio Publications

The following is a list of recent papers that include data produced using the Studio’s resources:

2024:

Bioorg Med Chem 2024 Nov 9:116:117990.

Exploring the rhodanine universe: Design and synthesis of fluorescent rhodanine-based derivatives as anti-fibrillar and anti-oligomer agents against α-synuclein and 2N4R tau

Ahmed A Elbatrawy, Taiwo A Ademoye, Heba Alnakhala, Arati Tripathi, Germán Plascencia-Villa, Xiongwei Zhu, George Perry, Ulf Dettmer, Jessica S Forti

Cell Rep Methods 2024 Nov 18;4(11):100901. Epub 2024 Nov 8.

MEA-NAP: A flexible network analysis pipeline for neuronal 2D and 3D organoid multielectrode recordings

Timothy P H Sit, Rachael C Feord, Alexander W E Dunn, Jeremi Chabros, David Oluigbo, Hugo H Smith, Lance Burn, Elise Chang, Alessio Boschi, Yin Yuan, George M Gibbons, Mahsa Khayat-Khoei, Francesco De Angelis, Erik Hemberg, Martin Hemberg, Madeline A Lancaster, Andras Lakatos, Stephen J Eglen, Ole Paulsen, Susanna B Mierau

NPJ Regen Med 2024 Oct 28;9(1):32.

Regeneration-specific promoter switching facilitates Mest expression in the mouse digit tip to modulate neutrophil response

Vivian Jou, Sophia M Peña, Jessica A Lehoczky

bioRxiv 2024 Aug 28:2023.11.04.565631.

Ultra-Long-Term Delivery of Hydrophilic Drugs Using Injectable In Situ Cross-Linked Depots

Sohyung Lee, Spencer Zhao, Weihua Jiang, Xinyang Chen, Lingyun Zhu, John Joseph, Eli Agus, Helna Baby Mary, Shumaim Barooj, Kai Slaughter, Krisco Cheung, James N Luo, Chetan Shukla, Jingjing Gao, Dongtak Lee, Biji Balakrishnan, Christopher Jiang, Amogh Gorantla, Sukyung Woo, Jeffrey M Karp, Nitin Joshi

Immunity 2024 Sep 10;57(9):2077-2094.e12.

A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance

Randall T Mertens, Aditya Misra, Peng Xiao, Seungbyn Baek, Joseph M Rone, Davide Mangani, Kisha N Sivanathan, Adedamola S Arojojoye, Samuel G Awuah, Insuk Lee, Guo-Ping Shi, Boryana Petrova, Jeannette R Brook, Ana C Anderson, Richard A Flavell, Naama Kanarek, Martin Hemberg, Roni Nowarski

Neuron 2024 Sep 4;112(17):2886-2909.e16.

Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions

Isabel Lam, Alain Ndayisaba, Amanda J Lewis, YuHong Fu, Giselle T Sagredo, Anastasia Kuzkina, Ludovica Zaccagnini, Meral Celikag, Jackson Sandoe, Ricardo L Sanz, Aazam Vahdatshoar, Timothy D Martin, Nader Morshed, Toru Ichihashi, Arati Tripathi, Nagendran Ramalingam, Charlotte Oettgen-Suazo, Theresa Bartels, Manel Boussouf, Max Schäbinger, Erinc Hallacli, Xin Jiang, Amrita Verma, Challana Tea, Zichen Wang, Hiroyuki Hakozaki, Xiao Yu, Kelly Hyles, Chansaem Park, Xinyuan Wang, Thorold W Theunissen, Haoyi Wang, Rudolf Jaenisch, Susan Lindquist, Beth Stevens, Nadia Stefanova, Gregor Wenning, Wilma D J van de Berg, Kelvin C Luk, Rosario Sanchez-Pernaute, Juan Carlos Gómez-Esteban, Daniel Felsky, Yasujiro Kiyota, Nidhi Sahni, S Stephen Yi, Chee Yeun Chung, Henning Stahlberg, Isidro Ferrer, Johannes Schöneberg, Stephen J Elledge, Ulf Dettmer, Glenda M Halliday, Tim Bartels, Vikram Khurana

Cell Mol Life Sci  2024 Aug 20;81(1):362.

RXR nuclear receptor signaling modulates lipid metabolism and triggers lysosomal clearance of alpha-synuclein in neuronal models of synucleinopathy

Arati Tripathi, Heba Alnakhala, Lisa Brontesi, Dennis Selkoe, Ulf Dettmer

Mucosal Immunol 2024 Jun 24:S1933-0219(24)00060-6.

Dietary protein modulates intestinal dendritic cells to establish mucosal homeostasis

Thais G Moreira, Laura M Cox, Patrick Da Silva, Davide Mangani, Marilia G De Oliveira, Giulia Escobar, Toby B Lanser, Liam Murphy, Eduardo L C Lobo, Omer Milstein, Christian D Gauthier, Ana Clara Guimarāes, Luke Schwerdtfeger, Mellicient N Ekwudo, Caroline Wasén, Shirong Liu, Gustavo B Menezes, Enio Ferreira, Galina Gabriely, Ana C Anderson, Ana Maria C Faria, Rafael M Rezende, Howard L Weiner

Sci Adv 2024 Jun 21;10(25):eadj9173.

Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia

Shamsuddin A Bhuiyan, Mengyi Xu, Lite Yang, Evangelia Semizoglou, Parth Bhatia, Katerina I Pantaleo, Ivan Tochitsky, Aakanksha Jain, Burcu Erdogan, Steven Blair, Victor Cat, Juliet M Mwirigi, Ishwarya Sankaranarayanan, Diana Tavares-Ferreira, Ursula Green, Lisa A McIlvried, Bryan A Copits, Zachariah Bertels, John S Del Rosario, Allie J Widman, Richard A Slivicki, Jiwon Yi, Reza Sharif-Naeini, Clifford J Woolf, Jochen K Lennerz, Jessica L Whited, Theodore J Price, Robert W Gereau Iv, William Renthal

bioRxiv 2024 Jun 15:2024.06.12.598713.

Regeneration-specific promoter switching facilitates Mest expression in the mouse digit tip to modulate neutrophil response

Vivian Jou, Sophia M Peña, Jessica A Lehoczky

Int J Mol Sci 2024 May 25;25(11):5754.

Temporal Characterization of the Amyloidogenic APPswe/PS1dE9;hAPOE4 Mouse Model of Alzheimer’s Disease

Martine B Grenon, Maria-Tzousi Papavergi, Praveen Bathini, Martin Sadowski, Cynthia A Lemere

Brain Commun  2024 May 3;6(4):fcae147.

NPJ Parkinsons Dis   2024 May 21;10(1):107.

A stem cell-based assay platform demonstrates alpha-synuclein dependent synaptic dysfunction in patient-derived cortical neurons

Andrew J White, Karis A Clark, Kellianne D Alexander, Nagendran Ramalingam, Tracy L Young-Pearse, Ulf Dettmer, Dennis J Selkoe, Gary P H Ho

Brain Commun  2024 May 3;6(4):fcae147.

High-salt diet induces microbiome dysregulation, neuroinflammation and anxiety in the chronic period after mild repetitive closed head injury in adolescent mice

Saef Izzy, Taha Yahya, Omar Albastaki, Tian Cao, Luke A Schwerdtfeger, Hadi Abou-El-Hassan, Kusha Chopra, Millicent N Ekwudo, Ugne Kurdeikaite, Isabelly M Verissimo, Danielle S LeServe, Toby B Lanser, Michael Aronchik, Marilia G Oliveira, Thais Moreira, Rafael Machado Rezende, Joseph El Khoury, Laura M Cox, Howard L Weiner, Ross Zafonte, Michael J Whalen

Cell 2024 Apr 1:S0092-8674(24)00254-X.

Charting the cellular biogeography in colitis reveals fibroblast trajectories and coordinated spatial remodeling

Paolo Cadinu, Kisha N. Sivanathan, Aditya Misra, Rosalind J. Xu, Davide Mangani, Evan Yang, Joseph M. Rone, Katherine Tooley, Yoon-Chul Kye, Lloyd Bod, Ludwig Geistlinger, Tyrone Lee, Noriaki Ono, Gang Wang, Liliana Sanmarco, Francisco J. Quintana, Ana C. Anderson, Vijay K. Kuchroo,  Jeffrey R. Moffitt, Roni Nowarski

bioRxiv 2024 Mar 17

A systems-biology approach connects aging mechanisms with Alzheimer’s disease pathogenesis

Matthew J Leventhal, Camila A Zanella, Byunguk Kang, Jiajie Peng, David Gritsch, Zhixiang Liao, Hassan Bukhari, Tao Wang, Ping-Chieh Pao, Serwah Danquah, Joseph Benetatos, Ralda Nehme, Samouil Farhi, Li-Huei Tsai, Xianjun Dong, Clemens R Scherzer, Mel B Feany, Ernest Fraenkel

Alzheimers Dement 2024 Mar 12.

Person-specific differences in ubiquitin-proteasome mediated proteostasis in human neurons

Yi-Chen Hsieh, Zachary M Augur, Mason Arbery, Nancy Ashour, Katharine Barrett, Richard V Pearse 2nd, Earvin S Tio, Duc M Duong, Daniel Felsky, Philip L De Jager, David A Bennett, Nicholas T Seyfried, Tracy L Young-Pearse

bioRxiv [Preprint]. 2024 Mar 7:2024.03.03.583145.

Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies

Sumaiya Nazeen, Xinyuan Wang, Dina Zielinski, Isabel Lam, Erinc Hallacli, Ping Xu, Elizabeth Ethier, Ronya Strom, Camila A Zanella, Vanitha Nithianandam, Dylan Ritter, Alexander Henderson, Nathalie Saurat, Jalwa Afroz, Andrew Nutter-Upham, Hadar Benyamini, Joseph Copty, Shyamsundar Ravishankar, Autumn Morrow, Jonathan Mitchel, Drew Neavin, Renuka Gupta, Nona Farbehi, Jennifer Grundman, Richard H Myers, Clemens R Scherzer, John Q Trojanowski, Vivianna M Van Deerlin, Antony A Cooper, Edward B Lee, Yaniv Erlich, Susan Lindquist, Jian Peng, Daniel H Geschwind, Joseph Powell, Lorenz Studer, Mel B Feany, Shamil R Sunyaev, Vikram Khurana

Nature 2024 Mar;627(8005):865-872.

Disease-associated astrocyte epigenetic memory promotes CNS pathology

Hong-Gyun Lee, Joseph M Rone, Zhaorong Li, Camilo Faust Akl, Seung Won Shin, Joon-Hyuk Lee, Lucas E Flausino, Florian Pernin, Chun-Cheih Chao, Kilian L Kleemann, Lena Srun, Tomer Illouz, Federico Giovannoni, Marc Charabati, Liliana M Sanmarco, Jessica E Kenison, Gavin Piester, Stephanie E J Zandee, Jack P Antel, Veit Rothhammer, Michael A Wheeler , Alexandre Prat, Iain C Clark, Francisco J Quintana

Brain Behav Immun 2024 Mar:117:242-254.

Gamma-delta T cells suppress microbial metabolites that activate striatal neurons and induce repetitive/compulsive behavior in mice

Laura M Cox, Bruna K Tatematsu , Lydia Guo, Danielle S LeServe, Julia Mayrink, Marilia G Oliveira, Dustin Donnelly, Roberta C Fonseca, Luisa Lemos, Toby B Lanser, Ana C Rosa, Juliana R Lopes, Luke A Schwerdtfeger, Gabriela F C Ribeiro, Eduardo L C Lobo, Thais G Moreira, Andre G Oliveira, Howard L Weiner, Rafael M Rezende

NPJ Parkinsons Dis 2024 Feb 29;10(1):47.

Generation of G51D and 3D mice reveals decreased α-synuclein tetramer-monomer ratios promote Parkinson’s disease phenotypes

Silke Nuber, Xiaoqun Zhang, Thomas D McCaffery, Tim E Moors, Marie-Alexandre Adom, Wolf N Hahn, Dylan Martin, Maria Ericsson, Arati Tripathi, Ulf Dettmer, Per Svenningsson, Dennis J Selkoe

Nat Genet 2024 Jan;56(1):37-50.

Perturbational phenotyping of human blood cells reveals genetically determined latent traits associated with subsets of common diseases

Max Homilius , Wandi Zhu , Samuel S Eddy , Patrick C Thompson, Huahua Zheng, Caleb N Warren , Chiara G Evans , David D Kim , Lucius L Xuan , Cissy Nsubuga , Zachary Strecker , Christopher J Pettit , Jungwoo Cho , Mikayla N Howie , Alexandra S Thaler , Evan Wilson , Bruce Wollison , Courtney Smith , Julia B Nascimben , Diana N Nascimben5, Gabriella M Lunati , Hassan C Folks , Matthew Cupelo , Suriya Sridaran , Carolyn Rheinstein , Taylor McClennen , Shinichi Goto , James G Truslow , Sara Vandenwijngaert , Calum A MacRae , Rahul C Deo 9

2023:

ACS Omega 2023 Dec 19;9(1):1216-1229.

 1,4-Diurea- and 1,4-Dithiourea-Substituted Aromatic Derivatives Selectively Inhibit α-Synuclein Oligomer Formation In Vitro

Susantha K Ganegamage , Eduardo Ramirez , Heba Alnakhala , Arati Tripathi , Cuong Calvin Duc Nguyen , Ashique Zami , Raluca Ostafe , Shiliang Tian , Ulf Dettmer2, Jessica S Fortin 

Alzheimers Dement 2023 Dec 2.

doi: 10.1002/alz.13557.

Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer’s disease patients

Jean-Pierre Bellier , Yuqi Cai , Sarah M Alam , Thorsten Wiederhold , Arica Aiello, Jonathan S Vogelgsang , Sabina Berretta , Jasmeer P Chhatwal , Dennis J Selkoe , Lei Liu 

Nat Immunol 2023 Nov;24(11):1839-1853.

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

Zhuoran Yin , Neta Rosenzweig , Kilian L Kleemann, Xiaoming Zhang , Wesley Brandão , Milica A Margeta , Caitlin Schroeder , Kisha N Sivanathan , Sebastian Silveira , Christian Gauthier , Dania Mallah , Kristen M Pitts , Ana Durao , Shawn Herron , Hannah Shorey , Yiran Cheng , Jen-Li Barry , Rajesh K Krishnan , Sam Wakelin , Jared Rhee , Anthony Yung , Michael Aronchik , Chao Wang , Nimansha Jain , Xin Bao , Emma Gerrits , Nieske Brouwer , Amy Deik , Daniel G Tenen, Tsuneya Ikezu , Nicolas G Santander , Gabriel L McKinsey, Caroline Baufeld , Dean Sheppard, Susanne Krasemann , Roni Nowarski , Bart J L Eggen , Clary Clish , Rudolph E Tanzi , Charlotte Madore , Thomas D Arnold , David M Holtzman , Oleg Butovsky 

Proc Natl Acad Sci U S A 2023 Sep 12;120(37)

Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer’s disease

Juliana R Lopes , Xiaoming Zhang , Julia Mayrink , Bruna K Tatematsu , Lydia Guo , Danielle S LeServe , Hadi Abou-El-Hassan , Felipe Rong , Maria J Dalton , Marilia G Oliveira , Toby B Lanser , Lei Liu , Oleg Butovsky , Rafael M Rezende , Howard L Weiner 

Biomaterials 2023 Sep:300:122179.

Self-oxygenation of engineered living tissues orchestrates osteogenic commitment of mesenchymal stem cells

Shabir Hassan , Ting Wang , Kun Shi , Yike Huang , Maria Elizabeth Urbina Lopez , Kaifeng Gan , Mo Chen , Niels Willemen , Haroon Kalam , Eder Luna-Ceron , Berivan Cecen , Gihan Daw Elbait , Jinghang Li , Luis Enrique Garcia-Rivera , Melvin Gurian , Mudassir Meraj Banday , Kisuk Yang , Myung Chul Lee , Weida Zhuang , Castro Johnbosco , Oju Jeon , Eben Alsberg , Jeroen Leijten , Su Ryon Shin

Cell Rep 2023 Aug 29;42(8):112994.

Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1

Hyo Lee , Aimee J Aylward , Richard V Pearse 2nd , Alexandra M Lish , Yi-Chen Hsieh , Zachary M Augur , Courtney R Benoit , Vicky Chou , Allison Knupp , Cheryl Pan , Srilakshmi Goberdhan , Duc M Duong , Nicholas T Seyfried , David A Bennett , Mariko F Taga , Kevin Huynh , Matthias Arnold , Peter J Meikle , Philip L De Jager , Vilas Menon , Jessica E Young , Tracy L Young-Pearse 

Dev Cell 2023 Aug 24:S1534-5807(23)00397-0.

Reconstructing human brown fat developmental trajectory in vitro

Jyoti Rao , Yannis Djeffal , Jerome Chal , Fabio Marchianò , Chih-Hao Wang , Ziad Al Tanoury , Svetlana Gapon , Alicia Mayeuf-Louchart , Ian Glass , Elizabeth M Sefton , Bianca Habermann , Gabrielle Kardon , Fiona M Watt , Yu-Hua Tseng , Olivier Pourquié

Nature 2023 Aug;620(7975):881-889.

Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells

Liliana M Sanmarco, Joseph M Rone , Carolina M Polonio , Gonzalo Fernandez Lahore , Federico Giovannoni , Kylynne Ferrara , Cristina Gutierrez-Vazquez , Ning Li , Anna Sokolovska , Agustin Plasencia ,   Payal Nanda , Evelin S Heck , Zhaorong Li , Hong-Gyun Lee , Chun-Cheih Chao , Claudia M Rejano-Gordillo , Pedro H Fonseca-Castro , Tomer Illouz , Mathias Linnerbauer , Jessica E Kenison, Rocky M Barilla, Daniel Farrenkopf , Nikolas A Stevens, Gavin Piester , Elizabeth N Chung , Lucas Dailey , Vijay K Kuchroo, David Hava, Michael A Wheeler , Clary Clish, Roni Nowarski , Eduardo Balsa , Jose M Lora , Francisco J Quintana 

Nat Neurosci 2023 Jul;26(7):1196-1207.

Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease

Zhuoran Yin , Shawn Herron, Sebastian Silveira , Kilian Kleemann , Christian Gauthier, Dania Mallah , Yiran Cheng , Milica A Margeta , Kristen M Pitts , Jen-Li Barry , Ayshwarya Subramanian , Hannah Shorey , Wesley Brandao , Ana Durao , Jean-Christophe Delpech , Charlotte Madore , Mark Jedrychowski , Amrendra K Ajay, Gopal Murugaiyan , Samuel W Hersh , Seiko Ikezu , Tsuneya Ikezu , Oleg Butovsky 

Nat Commun 2023 Jul 18;14(1):4286.

Vγ1 and Vγ4 gamma-delta T cells play opposing roles in the immunopathology of traumatic brain injury in males

Hadi Abou-El-Hassan , Rafael M Rezende , Saef Izzy , Galina Gabriely , Taha Yahya , Bruna K Tatematsu , Karl J Habashy , Juliana R Lopes , Gislane L V de Oliveira , Amir-Hadi Maghzi , Zhuoran Yin , Laura M Cox , Rajesh Krishnan , Oleg Butovsky , Howard L Weiner 

Nature 2023 Jul;619(7969):348-356

B-cell-specific checkpoint molecules that regulate anti-tumour immunity

Lloyd Bod , Yoon-Chul Kye , Jingwen Shi , Elena Torlai Triglia , Alexandra Schnell , Johannes Fessler , Stephen M Ostrowski , Max Y Von-Franque, Juhi R Kuchroo , Rocky M Barilla , Sarah Zaghouani , Elena Christian , Toni Marie Delorey , Kanishka Mohib , Sheng Xiao , Nadine Slingerland , Christopher J Giuliano , Orr Ashenberg , Zhaorong Li, David M Rothstein , David E Fisher, Orit Rozenblatt-Rosen , Arlene H Sharpe , Francisco J Quintana , Lionel Apetoh, Aviv Regev , Vijay K Kuchroo 

bioRxiv  2023 Jul 5:2023.07.04.547740.

Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia

Shamsuddin A Bhuiyan , Mengyi Xu , Lite Yang , Evangelia Semizoglou , Parth Bhatia , Katerina I Pantaleo , Ivan Tochitsky , Aakanksha Jain , Burcu Erdogan , Steven Blair , Victor Cat , Juliet M Mwirigi , Ishwarya Sankaranarayanan , Diana Tavares-Ferreira , Ursula Green , Lisa A McIlvried , Bryan A Copits , Zachariah Bertels , John S Del Rosario , Allie J Widman , Richard A Slivicki , Jiwon Yi , Clifford J Woolf , Jochen K Lennerz , Jessica L Whited , Theodore J Price , Robert W Gereau 4th , William Renthal 

ACS Omega 2023 May 23;8(22):20102-20115.

5-Nitro-1,2-benzothiazol-3-amine and N-Ethyl-1-[(ethylcarbamoyl)(5-nitro-1,2-benzothiazol-3-yl)amino]formamide Modulate α-Synuclein and Tau Aggregation

Eduardo Ramirez , Susantha K Ganegamage , Ahmed A Elbatrawy , Heba Alnakhala , Kazuma Shimanaka , Arati Tripathi , Sehong Min , Jean-Christophe Rochet , Ulf Dettmer , Jessica S Fortin

Research (Wash D C) 2023 Feb 27.

A 3D Bioprinted Gut Anaerobic Model for Studying Bacteria-Host Interactions

Liqin Cheng, Tingting Liu, Qiongg Liu, Liming Lian, Guosheng Tang, Luis Santiago Mille, Fabricio Romero García, Lars Engstrand, Yu Shrike Zhang, Juan Du

Nat Neurosci 2023 Jun 8.

Identification of a protective microglial state mediated by miR-155 and interferon-γ signaling in a mouse model of Alzheimer’s disease

Zhuoran Yin, Shawn Herron, Sebastian Silveira, Kilian Kleemann, Christian Gauthier, Dania Mallah, Yiran Cheng, Milica A Margeta, Kristen M Pitts, Jen-Li Barry, Ayshwarya Subramanian, Hannah Shorey, Wesley Brandao, Ana Durao, Jean-Christophe Delpech, Charlotte Madore, Mark Jedrychowski, Amrendra K Ajay, Gopal Murugaiyan, Samuel W Hersh, Seiko Ikezu, Tsuneya Ikezu, Oleg Butovsky

JCI Insight. 2023 Apr 24; 8(8): e164178.

MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity

Lydie Naulé, Alessandra Mancini, Sidney A. Pereira, Brandon M. Gassaway, John R. Lydeard, John C. Magnotto, Han Kyeol Kim, Joy Liang, Cynara Matos, Steven P. Gygi, Florian T. Merkle, Rona S. Carroll, Ana Paula Abreu, and Ursula B. Kaiser

Neuron, in. press

Abundant Aβ fibrils in ultracentrifugal supernatants of aqueous extracts from Alzheimer’s disease brains

Andrew M. Stern, Yang Yang, Shanxue Jin, Keitaro Yamashita, Angela L. Meunier, Wen Liu, Yuqi Cai, Maria Ericsson, Lei Liu, Michel Goedert, Sjors H.W. Scheres, Dennis J. Selkoe

Science 2023 Mar 10

Droplet-based forward genetic screening of astrocyte-microglia cross-talk

Michael A Wheeler, Iain C Clark, Hong-Gyun Lee, Zhaorong Li, Mathias Linnerbauer, Joseph M Rone, Manon Blain, Camilo Faust Akl, Gavin Piester, Federico Giovannoni, Marc Charabati, Joon-Hyuk Lee, Yoon-Chul Kye, Joshua Choi, Liliana M Sanmarco, Lena Srun, Elizabeth N Chung, Lucas E Flausino, Brian M Andersen, Veit Rothhammer, Hiroshi Yano, Tomer Illouz, Stephanie E J Zandee, Carolin Daniel, David Artis, Marco Prinz, Adam R Abate, Vijay K Kuchroo, Jack P Antel, Alexandre Prat, Francisco J Quintana

Nature 2023 Feb

Identification of astrocyte regulators by nucleic acid cytometry

Iain C Clark, Michael A Wheeler, Hong-Gyun Lee, Zhaorong Li, Liliana M Sanmarco, Shravan Thaploo, Carolina M Polonio, Seung Won Shin, Giulia Scalisi, Amy R Henry, Joseph M Rone, Federico Giovannoni, Marc Charabati, Camilo Faust Akl, Dulce M Aleman, Stephanie E J Zandee, Alexandre Prat, Daniel C Douek, Eli A Boritz, Francisco J Quintana, Adam R Abate

Nature 2023 Jan;613(7944):550-557.

Metabolic regulation of species-specific developmental rates

Margarete Diaz-Cuadros, Teemu P Miettinen, Owen S Skinner, Dylan Sheedy, Carlos Manlio Díaz-García, Svetlana Gapon, Alexis Hubaud, Gary Yellen, Scott R Manalis, William M Oldham, Olivier Pourquié

J Neurochem 2023 Jan 10.

The effects of KTKEGV repeat motif and intervening ATVA sequence on α-synuclein solubility and assembly

Lisa Brontesi, Thibaut Imberdis, Nagendran Ramalingam, Ulf Dettmer

Mol Ther Nucleic Acids 2023 Jan 2;31:265-275.

Secreted PGK1 and IGFBP2 contribute to the bystander effect of miR-10b gene editing in glioma

Yanhong Zhang, Rosalia Rabinovsky, Zhiyun Wei, Rachid El Fatimy, Evgeny Deforzh, Bai Luan, Leonid Peshkin, Erik J Uhlmann, Anna M Krichevsky

NPJ Parkinsons Dis 2023 Jan 16;9(1):4

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity

Nagendran Ramalingam, Shan-Xue Jin , Tim E Moors, Luis Fonseca-Ornelas, Kazuma Shimanaka, Shi Lei, Hugh P Cam, Aurelia Hays Watson, Lisa Brontesi, Lai Ding, Dinc Yasat Hacibaloglu, Haiyang Jiang, Se Joon Choi, Ellen Kanter, Lei Liu, Tim Bartels, Silke Nuber, David Sulzer, Eugene V Mosharov, Weisheng V Chen, Shaomin Li, Dennis J Selkoe, Ulf Dettmer

2022:

Nature 2022 Dec 21

Reconstruction and deconstruction of human somitogenesis in vitro

Yuchuan Miao, Yannis Djeffal, Alessandro De Simone, Kongju Zhu, Jong Gwan Lee, Ziqi Lu, Andrew Silberfeld, Jyoti Rao, Oscar A Tarazona, Alessandro Mongera, Pietro Rigoni, Margarete Diaz-Cuadros, Laura Min Sook Song, Stefano Di Talia, Olivier Pourquié

Nature 2022 Nov;611(7937):801-809.

Identification of environmental factors that promote intestinal inflammation

Liliana M Sanmarco, Chun-Cheih Chao, Yu-Chao Wang, Jessica E Kenison, Zhaorong Li , Joseph M Rone, Claudia M Rejano-Gordillo, Carolina M Polonio, Cristina Gutierrez-Vazquez, Gavin Piester, Agustin Plasencia, Lucinda Li, Federico Giovannoni, Hong-Gyun Lee, Camilo Faust Akl, Michael A Wheeler, Ivan Mascanfroni, Merja Jaronen, Moneera Alsuwailm, Patrick Hewson, Ada Yeste, Brian M Andersen, Diana G Franks, Chien-Jung Huang, Millicent Ekwudo, Emily C Tjon, Veit Rothhammer, Maisa Takenaka, Kalil Alves de Lima, Mathias Linnerbauer, Lydia Guo, Ruxandra Covacu, Hugo Queva, Pedro Henrique Fonseca-Castro, Maha Al Bladi, Laura M Cox, Kevin J Hodgetts, Mark E Hahn, Alexander Mildner, Joshua Korzenik, Russ Hauser, Scott B Snapper, Francisco J Quintana

Cell Rep  2022 Nov 22;41(8):111701.

En1 and Lmx1b do not recapitulate embryonic dorsal-ventral limb patterning functions during mouse digit tip regeneration

Gemma L Johnson, Morgan B Glasser, Julia F Charles, Jeffrey Duryea, Jessica A Lehoczky

Cerebellum  2022 Oct 3;1-21.

Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping

Alain Ndayisaba, Ariana T Pitaro, Andrew S Willett, Kristie A Jones, Claudio Melo de Gusmao, Abby L Olsen, Jisoo Kim, Eero Rissanen, Jared K Woods, Sharan R Srinivasan, Anna Nagy, Amanda Nagy, Merlyne Mesidor, Steven Cicero, Viharkumar Patel, Derek H Oakley, Idil Tuncali, Katherine Taglieri-Noble, Emily C Clark, Jordan Paulson, Richard C Krolewski, Gary P Ho, Albert Y Hung, Anne-Marie Wills, Michael T Hayes, Jason P Macmore, Luigi Warren, Pamela G Bower, Carol B Langer, Lawrence R Kellerman, Christopher W Humphreys, Bonnie I Glanz, Elodi J Dielubanza, Matthew P Frosch, Roy L Freeman, Christopher H Gibbons, Nadia Stefanova, Tanuja Chitnis, Howard L Weiner, Clemens R Scherzer, Sonja W Scholz, Dana Vuzman, Laura M Cox, Gregor Wenning, Jeremy D Schmahmann, Peter Novak, Geoffrey S Young, Mel B Feany, Tarun Singhal, Vikram Khurana

Mol Neurodegener 2022 Sep 21;17(1):61.

Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity

Yi-Chen Hsieh, Joseph Negri, Amy He, Richard V Pearse 2nd, Lei Liu, Duc M Duong, Lori B Chibnik, David A Bennett, Nicholas T Seyfried, Tracy L Young-Pearse

NPJ Parkinsons Dis 2022 Sep 16;8(1):118.

Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons

Luis Fonseca-Ornelas, Jonathan M S Stricker, Stephanie Soriano-Cruz, Beatrice Weykopf, Ulf Dettmer, Christina R Muratore, Clemens R Scherzer, Dennis J Selkoe

Stem Cell Reports  2022 Sep 13;17(9):2111-2126.

Loss of endosomal exchanger NHE6 leads to pathological changes in tau in human neurons

Marty A Fernandez, Fatmata Bah, Li Ma, YouJin Lee, Michael Schmidt, Elizabeth Welch, Eric M Morrow, Tracy L Young-Pearse

Immunity  2022 Sep 13;55(9):1627-1644.e7.

Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma

Milica A Margeta, Zhuoran Yin, Charlotte Madore, Kristen M Pitts, Sophia M Letcher, Jing Tang, Shuhong Jiang, Christian D Gauthier, Sebastian R Silveira, Caitlin M Schroeder, Eleonora M Lad, Alan D Proia, Rudolph E Tanzi, David M Holtzman, Susanne Krasemann, Dong Feng Chen, Oleg Butovsky

Mol Cell  2022 Mar 29;S1097-2765(22)00256-8.

Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma

Evgeny Deforzh, Erik J Uhlmann, Eashita Das, Aleksandra Galitsyna, Ramil Arora, Harini Saravanan, Rosalia Rabinovsky, Aditya D Wirawan, Nadiya M Teplyuk, Rachid El Fatimy, Sucika Perumalla, Anirudh Jairam, Zhiyun Wei, Leonid Mirny, Anna M Krichevsky

Cell 2022 Jun 9;185(12):2035-2056.e33.

The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability

Erinc Hallacli, Can Kayatekin, Sumaiya Nazeen, Xiou H Wang, Zoe Sheinkopf, Shubhangi Sathyakumar, Souvarish Sarkar, Xin Jiang, Xianjun Dong, Roberto Di Maio, Wen Wang, Matthew T Keeney, Daniel Felsky, Jackson Sandoe, Aazam Vahdatshoar, Namrata D Udeshi, D R Mani, Steven A Carr, Susan Lindquist, Philip L De Jager, David P Bartel, Chad L Myers, J Timothy Greenamyre, Mel B Feany, Shamil R Sunyaev, Chee Yeun Chung, Vikram Khurana

NPJ Parkinsons Dis 2022 Jun 9;8(1):74.

Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy

Saranna Fanning, Haley Cirka, Jennifer L Thies, Jooyoung Jeong, Sarah M Niemi, Joon Yoon, Gary P H Ho, Julian A Pacheco, Ulf Dettmer, Lei Liu, Clary B Clish, Kevin J Hodgetts, John N Hutchinson, Christina R Muratore, Guy A Caldwell, Kim A Caldwell, Dennis Selkoe

Nat Commun 2022 Jun 9;13(1):3317.

Molecularly cleavable bioinks facilitate high-performance digital light processing-based bioprinting of functional volumetric soft tissues

Mian Wang, Wanlu Li, Jin Hao, Arthur Gonzales 3rd, Zhibo Zhao, Regina Sanchez Flores, Xiao Kuang, Xuan Mu, Terry Ching, Guosheng Tang, Zeyu Luo, Carlos Ezio Garciamendez-Mijares, Jugal Kishore Sahoo, Michael F Wells, Gengle Niu, Prajwal Agrawal, Alfredo Quiñones-Hinojosa, Kevin Eggan, Yu Shrike Zhang

Neuron 2022 Jun 1;110(11):1806-1821.e8.

Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine

Lite Yang, Mengyi Xu, Shamsuddin A Bhuiyan, Jia Li, Jun Zhao, Randall J Cohrs, Justin T Susterich, Sylvia Signorelli, Ursula Green, James R Stone, Dan Levy, Jochen K Lennerz, William Renthal

Brain  2022 Jan 27

A calcium-sensitive antibody isolates soluble amyloid-β aggregates and fibrils from Alzheimer’s disease brain

Andrew M Stern, Lei Liu, Shanxue Jin, Wen Liu, Angela L Meunier, Maria Ericsson, Michael B Miller, Megan Batson, Tingwan Sun, Sagar Kathuria, David Reczek, Laurent Pradier, Dennis J Selkoe

J Am Soc Nephrol 2022 Jan 28;ASN.2021020140.

Integrin α5 Is Regulated by miR-218-5p in Endothelial Progenitor Cells

Jialing Liu, Yi Li, Lingna Lyu, Liang Xiao, Aliza Anwar Memon, Xin Yu, Arvin Halim, Shivani Patel, Abdikheyre Osman, Wenqing Yin, Jie Jiang, Said Naini, Kenneth Lim, Aifeng Zhang, Jonathan Williams, Ruth Koester, Kevin Zeng Qi, Quynh-Anh Fucci, Lai Ding, Steven Chang, Ankit Patel, Yutaro Mori, Advika Chaudhari, Aaron Bao, Jia Liu, Tzongshi Lu, Andrew Siedlecki

Mol Psychiatry  2022 Feb 23.

APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons

Chun-I Wu, Elizabeth A Vinton, Richard V Pearse 2nd, Keunjung Heo, Aimee J Aylward, Yi-Chen Hsieh, Yan Bi, Sopefoluwa Adeleye, Seeley Fancher, Duc M Duong, Nicholas T Seyfried, Thomas L Schwarz , Tracy L Young-Pearse

J Neurosci  2022 Jan 26;

Pathogenic mechanisms of cytosolic and membrane-enriched α-synuclein converge on fatty acid homeostasis

Arati Tripathi, Heba Alnakhala, Elizabeth Terry-Kantor, Andrew Newman, Lei Liu, Thibaut Imberdis, Saranna Fanning, Silke Nuber, Nagendran Ramalingam, Dennis Selkoe, Ulf Dettmer

Mol Cancer  2022 Jan 15;21(1):17.

A nuclear function for an oncogenic microRNA as a modulator of snRNA and splicing

Rachid El Fatimy, Yanhong Zhang, Evgeny Deforzh, Mahalakshmi Ramadas, Harini Saravanan, Zhiyun Wei, Rosalia Rabinovsky, Nadiya M Teplyuk, Erik J Uhlmann, Anna M Krichevsky

Immunity  2022 Jan 11;55(1):159-173.e9.

Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function

Danyang He, Heping Xu, Huiyuan Zhang, Ruihan Tang, Yangning Lan, Ruxiao Xing, Shaomin Li, Elena Christian, Yu Hou, Paul Lorello, Barbara Caldarone, Jiarui Ding, Lan Nguyen, Danielle Dionne, Pratiksha Thakore, Alexandra Schnell, Jun R Huh, Orit Rozenblatt-Rosen, Aviv Regev, Vijay K Kuchroo

2021:

Adv Healthc Mater  2021 Dec 31

Mimicking Native Heart Tissue Physiology and Pathology in Silk Fibroin Constructs through a Perfusion-Based Dynamic Mechanical Stimulation Microdevice

Shreya Mehrotra, Bruna Alice Gomes de Melo, Mario Miscuglio, Kiavash Kiaee, Su Ryon Shin, Biman B Mandal

J Neuropathol Exp Neurol  2021 Dec 29;80(12):1117-1124.

Tumor-Derived Cell Culture Model for the Investigation of Meningioma Biology

Erik J Uhlmann, Rosalia Rabinovsky, Hemant Varma, Rachid El Fatimy, Ekkehard M Kasper, Justin M Moore, Rafael A Vega, Ajith J Thomas, Ronald L Alterman, Martina Stippler, Matthew P Anderson, Erik N Uhlmann, Franciela C Kipper, Anna M Krichevsky

Adv Mater  2021 Dec 21

Vertical Extrusion Cryo(bio)printing for Anisotropic Tissue Manufacturing

Zeyu Luo, Guosheng Tang, Hossein Ravanbakhsh, Wanlu Li, Mian Wang, Xiao Kuang, Carlos Ezio Garciamendez-Mijares, Liming Lian, Sili Yi, Junlong Liao, Maobin Xie, Jie Guo, Zongke Zhou, Yu Shrike Zhang

Adv Mater 2021 Oct 5;e2107038.

Digital Light Processing Based Bioprinting with Composable Gradients

Mian Wang, Wanlu Li, Luis S Mille, Terry Ching, Zeyu Luo, Guosheng Tang, Carlos Ezio Garciamendez, Ami Lesha, Michinao Hashimoto, Yu Shrike Zhang

Sci Adv 2021 Oct 29;7(44):eabk2775.

ATP-binding cassette protein ABCF1 couples transcription and genome surveillance in embryonic stem cells through low-complexity domain

Eun-Bee Choi, Munender Vodnala, Madeleine Zerbato, Jianing Wang, Jaclyn J Ho, Carla Inouye, Lai Ding, Yick W Fong

Alzheimers Dement  2021 Sep 22.  doi: 10.1002/alz.12457.

An ultra-sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma

Lei Liu, Hyunchang Kwak, Trebor L Lawton, Shan-Xue Jin  , Angela L Meunier  , Yifan Dang  , Beth Ostaszewski  , Alison C Pietras, Andrew M Stern, Dennis J Selkoe

Neuron 2021 Aug 26;S0896-6273(21)00578-X.

Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors

Valentina N Lagomarsino, Richard V Pearse 2nd, Lei Liu, Yi-Chen Hsieh, Marty A Fernandez, Elizabeth A Vinton, Daniel Paull, Daniel Felsky, Shinya Tasaki, Chris Gaiteri, Badri Vardarajan, Hyo Lee, Christina R Muratore, Courtney R Benoit, Vicky Chou, Seeley B Fancher, Amy He, Julie P Merchant, Duc M Duong, Hector Martinez, Monica Zhou, Fatmata Bah, Maria A Vicent, Jonathan M S Stricker, Jishu Xu, Eric B Dammer, Allan I Levey, Lori B Chibnik, Vilas Menon, Nicholas T Seyfried, Philip L De Jager, Scott Noggle, Dennis J Selkoe, David A Bennett, Tracy L Young-Pearse

Nat Commun 2021 Aug 13;12(1):4907.

PD-L1 + and XCR1 + dendritic cells are region-specific regulators of gut homeostasis

Thais G Moreira, Davide Mangani, Laura M Cox, Jeffrey Leibowitz, Eduardo L C Lobo, Mariana A Oliveira, Christian D Gauthier, Brenda N Nakagaki, Valerie Willocq, Anya Song, Lydia Guo, David C A Lima, Gopal Murugaiyan, Oleg Butovsky, Galina Gabriely, Ana C Anderson, Rafael M Rezende, Ana Maria C Faria, Howard L Weiner

Bio Protoc  2021 Aug 5;11(15):e4102.

Isolation of Nuclei from Mouse Dorsal Root Ganglia for Single-nucleus Genomics

Lite Yang, Ivan Tochitsky, Clifford J Woolf, William Renthal

Proc Natl Acad Sci USA 2021 Jul 13;118(28):e2022960118.

Prednisolone rescues Duchenne muscular dystrophy phenotypes in human pluripotent stem cell-derived skeletal muscle in vitro

Ziad Al Tanoury, John F Zimmerman, Jyoti Rao, Daniel Sieiro, Harold M McNamara, Thomas Cherrier, Alejandra Rodríguez-delaRosa, Aurore Hick-Colin, Fanny Bousson, Charlotte Fugier-Schmucker, Fabio Marchiano, Bianca Habermann, Jérome Chal, Alexander P Nesmith, Svetlana Gapon, Erica Wagner, Vandana A Gupta, Rhonda Bassel-Duby, Eric N Olson, Adam E Cohen, Kevin Kit Parker, Olivier Pourquié

Elife2021 Jul 6;10:e64819.

Dynamics of primitive streak regression controls the fate of neuromesodermal progenitors in the chicken embryo

Charlene Guillot, Yannis Djeffal, Arthur Michaut, Brian Rabe, Olivier Pourquié

Proc Natl Acad Sci U S A  2021 Jul 13;118(28):e2022960118.

Prednisolone rescues Duchenne muscular dystrophy phenotypes in human pluripotent stem cell-derived skeletal muscle in vitro

Ziad Al Tanoury, John F Zimmerman, Jyoti Rao, Daniel Sieiro, Harold M McNamara, Thomas Cherrier, Alejandra Rodríguez-delaRosa, Aurore Hick-Colin, Fanny Bousson, Charlotte Fugier-Schmucker, Fabio Marchiano, Bianca Habermann, Jérome Chal, Alexander P Nesmith, Svetlana Gapon, Erica Wagner, Vandana A Gupta, Rhonda Bassel-Duby, Eric N Olson, Adam E Cohen, Kevin Kit Parker, Olivier Pourquié 

Cell Rep2021 Jul 6;36(1):109333.

Altered conformation of α-synuclein drives dysfunction of synaptic vesicles in a synaptosomal model of Parkinson’s disease

Luis Fonseca-Ornelas, Thibault Viennet, Matteo Rovere, Haiyang Jiang, Lei Liu, Silke Nuber, Maria Ericsson, Haribabu Arthanari, Dennis J Selkoe 

Hum Mol Genet2021 Jul 12;ddab188.

Excess membrane binding of monomeric alpha-, beta-, and gamma-synuclein is invariably associated with inclusion formation and toxicity

Tae-Eun Kim, Andrew J Newman, Thibaut Imberdis, Lisa Brontesi, Arati Tripathi, Nagendran Ramalingam, Saranna Fanning, Dennis Selkoe, Ulf Dettmer 

Nat Med2021 Jul;27(7):1212-1222.

Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease

Benjamin M Scott , Cristina Gutiérrez-Vázquez , Liliana M Sanmarco  , Jessica A da Silva Pereira, Zhaorong Li  , Agustín Plasencia  , Patrick Hewson, Laura M Cox, Madelynn O’Brien, Steven K Chen, Pedro M Moraes-Vieira, Belinda S W Chang, Sergio G Peisajovich , Francisco J Quintana

PLoS Pathog  2021 May 6;17(5):e1009557.

Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection

Tiffany LinDaisy QuellierJeffrey LambTiphaine VoisinPankaj BaralFelix BockAlfrun SchönbergRossen MirchevGerald PierIsaac ChiuMihaela Gadjeva 

Proc Natl Acad Sci 2021 May 11;118(19):e2016146118

Reversed-engineered human alveolar lung-on-a-chip model

Di Huang, Tingting Liu, Junlong Liao, Sushila Maharjan, Xin Xie, Montserrat Pérez, Ingrid Anaya, Shiwei Wang, Alan Tirado Mayer, Zhixin Kang, Weijia Kong, Valerio Luca Mainardi, Carlos Ezio Garciamendez-Mijares, Germán García Martínez, Matteo Moretti, Weijia Zhang, Zhongze Gu, Amir M Ghaemmaghami, Yu Shrike Zhang

Science 2021 Apr 23;372(6540):eabf1230.

Barcoded viral tracing of single-cell interactions in central nervous system inflammation

Iain C Clark, Cristina Gutiérrez-Vázquez, Michael A Wheeler, Zhaorong Li, Veit Rothhammer, Mathias Linnerbauer, Liliana M Sanmarco, Lydia Guo, Manon Blain, Stephanie E J Zandee, Chun-Cheih Chao, Katelyn V Batterman, Marius Schwabenland, Peter Lotfy, Amalia Tejeda-Velarde, Patrick Hewson, Carolina Manganeli Polonio, Michael W Shultis, Yasmin Salem, Emily C Tjon, Pedro H Fonseca-Castro, Davis M Borucki, Kalil Alves de Lima, Agustin Plasencia, Adam R Abate, Douglas L Rosene, Kevin J Hodgetts Marco Prinz, Jack P Antel, Alexandre Prat, Francisco J Quintana

Nature  2021 Feb;590(7846):473-479. doi: 10.1038/s41586-020-03116-4. Epub 2021 Jan 6.

Gut-licensed IFNγ + NK cells drive LAMP1 + TRAIL + anti-inflammatory astrocytes

Liliana M Sanmarco, Michael A Wheeler, Cristina Gutiérrez-Vázquez, Carolina Manganeli Polonio, Mathias Linnerbauer, Felipe A Pinho-Ribeiro, Zhaorong Li, Federico Giovannoni, Katelyn V Batterman, Giulia Scalisi, Stephanie E J Zandee, Evelyn S Heck, Moneera Alsuwailm, Douglas L Rosene, Burkhard Becher, Isaac M Chiu, Alexandre Prat, Francisco J Quintana

Mov Disord 2021 Feb;36(2):348-359.doi: 10.1002/mds.28346. Epub 2020 Oct 26.

Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity

Gary P H Ho Nagendran Ramalingam Thibaut Imberdis Erin C Wilkie Ulf Dettmer Dennis J Selkoe 

Ann Neurol 2021 Jan;89(1):74-90. doi: 10.1002/ana.25920. Epub 2020 Oct 23.

A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice

Silke Nuber, Alice Y Nam, Molly M Rajsombath , Haley Cirka , Xiaoping Hronowski , Junmin Wang , Kevin Hodgetts , Liubov S Kalinichenko , Christian P Müller , Vera Lambrecht , Jürgen Winkler , Andreas Weihofen , Thibaut Imberdis , Ulf Dettmer , Saranna Fanning , Dennis J Selkoe 

2020:

Neuron 2020 Oct 14;108(1):128-144.e9.

Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury

William Renthal, Ivan Tochitsky, Lite Yang, Yung-Chih Cheng, Emmy Li, Riki Kawaguchi, Daniel H Geschwind, Clifford J Woolf

Mov Disord  2020 May;35(5):760-773.  doi: 10.1002/mds.27994. Epub 2020 Feb 8.

Lysosome and Inflammatory Defects in GBA1-Mutant Astrocytes Are Normalized by LRRK2 Inhibition

Anwesha Sanyal , Mark P DeAndrade , Hailey S Novis , Steven Lin , Jianjun Chang, Nathalie Lengacher , Julianna J Tomlinson , Malú G Tansey , Matthew J LaVoie 

Nature  2020 Feb;578(7796):593-599. doi: 10.1038/s41586-020-1999-0. Epub 2020 Feb 12.

MAFG-driven astrocytes promote CNS inflammation

Michael A Wheeler, Iain C Clark, Emily C Tjon, Zhaorong Li, Stephanie E J Zandee, Charles P Couturier, Brianna R Watson, Giulia Scalisi, Sarah Alkwai, Veit Rothhammer, Assaf Rotem, John A Heyman, Shravan Thaploo, Liliana M Sanmarco, Jiannis Ragoussis, David A Weitz , Kevin Petrecca, Jeffrey R Moffitt, Burkhard Becher, Jack P Antel, Alexandre Prat, Francisco J Quintana

Nature Neuroscience volume 23, pages939–951(2020)

AHR is a Zika virus host factor and a candidate target for antiviral therapy

Federico Giovannoni, Irene Bosch, Carolina Manganeli Polonio, María F. Torti, Michael A. Wheeler, Zhaorong Li, Leonardo Romorini, María S. Rodriguez Varela, Veit Rothhammer, Andreia Barroso, Emily C. Tjon, Liliana M. Sanmarco, Maisa C. Takenaka, Seyed Mohamad Sadegh Modaresi, Cristina Gutiérrez-Vázquez, Nágela Ghabdan Zanluqui, Nilton Barreto dos Santos, Carolina Demarchi Munhoz, Zhongyan Wang, Elsa B. Damonte, David Sherr, Lee Gehrke, Jean Pierre Schatzmann Peron, Cybele C. Garcia & Francisco J. Quintana

Biofabrication  10 November 2020  https://doi.org/10.1088/1758-5090/abc1be

Toward a Neurospheroid Niche Model: Optimizing Embedded 3D Bioprinting for Fabrication of Neurospheroid Brain-like Co-culture Constructs

Yi-Chen Li, Yasamin Jodat, Roya Samanipour, Giulio Zorzi, Kai Zhu, Minoru Hirano, Karen Chang, Adnan Arnaout, Shabir Hassan, Navneet Matharu, Ali Khademhosseini, Mina Hoorfar, Su Ryon Shin.

Small. 23 October 2020 https://doi.org/10.1002/smll.202004258

A Heart-Breast Cancer-on-a-Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy

Junmin Lee, Shreya Mehrotra, Elaheh Zare-Eelanjegh, Raquel Rodrigues, Alireza Akbarinejad, David Ge, Luca Amato, Kiavash Kiaee, YongCong Fang, Aliza Rosenkranz, Wendy Keung, Biman B. Mandal, Ronald A Li, Ting Zhang, HeaYeon Lee, Mehmet Remzi Dokmeci, Yu Shrike Zhang, Ali Khademhosseini, Su Ryon Shin.

Adv Sci (Weinh) 2020 Jan 10;7(5):1901878. doi: 10.1002/advs.201901878. eCollection 2020 Mar.

A 3D-Printed Hybrid Nasal Cartilage with Functional Electronic Olfaction

Yasamin A Jodat , Kiavash Kiaee , Daniel Vela Jarquin , Rosakaren Ludivina De la Garza Hernández 1, Ting Wang , Sudeep Joshi , Zahra Rezaei , Bruna Alice Gomes de Melo , David Ge , Manu S Mannoor , Su Ryon Shin 

Dev Cell  2020 Feb 24;52(4):525-540.e5. doi: 10.1016/j.devcel.2020.01.026.

Cellular Heterogeneity and Lineage Restriction during Mouse Digit Tip Regeneration at Single-Cell Resolution

Gemma L Johnson, Erick J Masias, Jessica A Lehoczky 

Nat Commun  2020 Mar 9;11(1):1267. doi: 10.1038/s41467-020-14997-4.

Complexation-inducedresolution enhancement of 3D-printed hydrogel constructs

Jiaxing Gong , Carl C L Schuurmans , Anne Metje van Genderen , Xia Cao , Wanlu Li , Feng Cheng , Jacqueline Jialu He , Arturo López , Valentin Huerta , Jennifer Manríquez , Ruiquan Li , Hongbin Li , Clément Delavaux , Shikha Sebastian , Pamela E Capendale , Huiming Wang , Jingwei Xie , Mengfei Yu , Rosalinde Masereeuw , Tina Vermonden , Yu Shrike Zhang 

DEVELOPMENT  2020 Jun26; 14(12):dev18344. doi: 10.1242

Differentiation of the human PAX7-positive myogenic precursors/satellite cell lineage in vitro

Ziad Al Tanoury, Jyoti Rao, Olivier Tassy, Bénédicte Gobert, Svetlana Gapon, Jean-Marie Garnier, Erica Wagner, Aurore Hick, Arielle Hall, Emanuela Gussoni, Olivier Pourquié

Alzheimers Res Ther. 2020 Jan 13;12(1):12

Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer’s-like mice.

Crehan H, Liu B, Kleinschmidt M, Rahfeld JU, Le KX, Caldarone BJ, Frost JL, Hettmann T, Hutter-Paier B, O’Nuallain B, Park MA, DiCarli MF, Lues I, Schilling S, Lemere CA

iScience  2020 Aug 21;23(8):101420. doi: 10.1016/j.isci.2020.101420. Epub 2020 Jul 29.

Glioblastoma-Derived Extracellular Vesicles Facilitate Transformation of Astrocytes via Reprogramming Oncogenic Metabolism

Ailiang Zeng , Zhiyun Wei , Rosalia Rabinovsky , Hyun Jung Jun , Rachid El Fatimy , Evgeny Deforzh , Ramil Arora , Yizheng Yao , Shun Yao , Wei Yan , Erik J Uhlmann , Alain Charest , Yongping You , Anna M Krichevsky 

Cell Rep. 2020 Feb 18;30(7):2065-2074.e4. doi: 10.1016/j.celrep.2020.01.073. PMID: 32075753

Glioma-Derived miRNA-Containing Extracellular Vesicles Induce Angiogenesis by Reprogramming Brain Endothelial Cells.

Lucero R, Zappulli V, Sammarco A, Murillo OD, Cheah PS, Srinivasan S, Tai E, Ting DT, Wei Z, Roth ME, Laurent LC, Krichevsky AM, Breakefield XO, Milosavljevic A. 

Methods  2020 Apr 8;S1046-2023(20)30047-5. doi: 10.1016/j.ymeth.2020.04.003. 

Investigating lymphangiogenesis in a sacrificially bioprinted volumetric model of breast tumor tissue

Tingting Liu , Qiong Liu , Ingrid Anaya , Di Huang , Weijia Kong , Luis S Mille , Yu Shrike Zhang 

Front Neurosci  2020 May 15;14:442.  doi: 10.3389/fnins.2020.00442. eCollection 2020.

LRRK2 Kinase Inhibition Rescues Deficits in Lysosome Function Due to Heterozygous GBA1 Expression in Human iPSC-Derived Neurons

Anwesha Sanyal , Hailey S Novis , Emile Gasser , Steven Lin , Matthew J LaVoie 

Adv Funct Mater  2020 Mar 17;30(12):1907436. doi: 10.1002/adfm.201907436. Epub 2020 Jan 20.

Nonmulberry Silk Based Ink for Fabricating Mechanically Robust Cardiac Patches and Endothelialized Myocardium-on-a-Chip Application

Shreya Mehrotra , Bruna A G de Melo , Minoru Hirano , Wendy Keung , Ronald A Li , Biman B Mandal , Su Ryon Shin 

J Am Soc Nephrol  2020 Jul;31(7):1479-1495.  doi: 10.1681/ASN.2019101032. Epub 2020 Jun 15.

Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis

Di Feng, Mukesh Kumar, Jan Muntel , Susan B Gurley , Gabriel Birrane , Isaac E Stillman , Lai Ding, Minxian Wang , Saima Ahmed , Johannes Schlondorff , Seth L Alper , Tom Ferrante , Susan L Marquez , Carlos F Ng, Richard Novak , Donald E Ingber , Hanno Steen , Martin R Pollak 

Acta Neuropathol  2020 Mar;139(3):503-526. doi: 10.1007/s00401-019-02114-9. Epub 2019 Dec 18.

PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

Grant T Corbett, Zemin Wang, Wei Hong, Marti Colom-Cadena, Jamie Rose, Meichen Liao, Adhana Asfaw, Tia C Hall , Lai Ding , Alexandra DeSousa , Matthew P Frosch , John Collinge , David A Harris, Michael S Perkinton, Tara L Spires-Jones, Tracy L Young-Pearse, Andrew Billinton, Dominic M Walsh

2019:

Cell  2019 Dec 12;179(7):1483-1498.e22. doi: 10.1016/j.cell.2019.11.016. Epub 2019 Dec 5.

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

Chun-Cheih Chao, Cristina Gutiérrez-Vázquez, Veit Rothhammer, Lior Mayo, Michael A Wheeler, Emily C Tjon, Stephanie E J Zandee, Manon Blain, Kalil Alves de Lima, Maisa C Takenaka, Julian Avila-Pacheco, Patrick Hewson, Lei Liu, Liliana M Sanmarco, Davis M Borucki, Gabriel Z Lipof, Sunia A Trauger, Clary B Clish, Jack P Antel, Alexandre Prat, Francisco J Quintana

Nat Neurosci 2019 May;22(5):729-740. doi: 10.1038/s41593-019-0370-y. Epub 2019 Apr 8.

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

Maisa C Takenaka, Galina Gabriely, Veit Rothhammer, Ivan D Mascanfroni, Michael A Wheeler, Chun-Cheih Chao, Cristina Gutiérrez-Vázquez, Jessica Kenison, Emily C Tjon, Andreia Barroso, Tyler Vandeventer, Kalil Alves de Lima, Sonja Rothweiler, Lior Mayo, Soufiene Ghannam, Stephanie Zandee, Luke Healy, David Sherr, Mauricio F Farez , Alexandre Prat , Jack Antel, David A Reardon, Hailei Zhang, Simon C Robson, Gad Getz, Howard L Weiner, Francisco J Quintana

Cell 2019 Jan 24;176(3):581-596.e18. doi: 10.1016/j.cell.2018.12.012. Epub 2019 Jan 17.

Environmental Control of Astrocyte Pathogenic Activities in CNS Inflammation

Michael A Wheeler, Merja Jaronen, Ruxandra Covacu, Stephanie E J Zandee, Giulia Scalisi, Veit Rothhammer, Emily C Tjon, Chun-Cheih Chao, Jessica E Kenison, Manon Blain, Vijayaraghava T S Rao, Patrick Hewson, Andreia Barroso, Cristina Gutiérrez-Vázquez, Alexandre Prat, Jack P Antel, Russ Hauser, Francisco J Quintana

2018:

Transl Psychiatry 2018 Nov 8;8(1):245.

Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression

Priya Srikanth , Valentina N Lagomarsino, Richard V Pearse , Meichen Liao, Sulagna Ghosh, Ralda Nehme, Nicholas Seyfried, Kevin Eggan, Tracy L Young-Pearse

Nat Commun 2018 Nov 1;9(1):4578.

Acute microglia ablation induces neurodegeneration in the somatosensory system

Stephen J Rubino, Lior Mayo, Isabella Wimmer, Victoria Siedler, Florian Brunner, Simon Hametner, Asaf Madi, Amanda Lanser, Thais Moreira, Dustin Donnelly, Laura Cox, Rafael Machado Rezende, Oleg Butovsky, Hans Lassmann, Howard L Weiner 

Acta Neuropathol 2018 Oct;136(4):537-555.

MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways

Rachid El Fatimy, Shaomin Li, Zhicheng Chen, Tasnim Mushannen, Sree Gongala, Zhiyun Wei, Darrick T Balu, Rosalia Rabinovsky, Adam Cantlon, Abdallah Elkhal, Dennis J Selkoe, Kai C Sonntag, Dominic M Walsh, Anna M Krichevsky

EMBO Mol Med 2018 Sep;10(9):e8931.

Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β

Huixin Xu , Molly M Rajsombath , Pia Weikop , Dennis J Selkoe 

Nat Commun 2018 Jul 11;9(1):2676.

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease

Ming Jin, Brian O’Nuallain, Wei Hong, Justin Boyd, Valentina N Lagomarsino, Tiernan T O’Malley, Wen Liu, Charles R Vanderburg, Matthew P Frosch, Tracy Young-Pearse, Dennis J Selkoe, Dominic M Walsh

Nat Commun 2018 Aug 8;9(1):3151

γδ T cells control humoral immune response by inducing T follicular helper cell differentiation

Rafael M Rezende, Amanda J Lanser, Stephen Rubino, Chantal Kuhn, Nathaniel Skillin, Thais G Moreira, Shirong Liu, Galina Gabriely, Bruna A David, Gustavo B Menezes, Howard L Weiner

Last Updated on December 3, 2024 by PIN Admin